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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-YD1130
YD1130

Chemical Structure : YD1130

CAS No.: 3062375-81-6

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YD1130 (YD-1130)

货号: PC-23237Not For Human Use, Lab Use Only.

YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs.

    物理化学性质&存储条件

    分子量 495.40
    分子式 C19H23BrN6O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3R,4R,5S)-2-(6-amino-9H-purin-9-yl)-5-(((2-((3-bromobenzyl)amino)ethyl)thio)methyl)tetrahydrofuran-3,4-diol

    参考文献

    1. Deng Y, et al. J Med Chem. 2024 Oct 3. doi: 10.1021/acs.jmedchem.4c01041.

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