Igermetostat | EZH2 inhibitor | Probechem Biochemicals

Chemical Structure : Igermetostat

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Igermetostat (XNW-5004, XNW5004)

货号: PC-23098Not For Human Use, Lab Use Only.

Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2.

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生物&药学活性

Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2.
XNW5004 significantly suppresses level of H3K27Me3, arrests cell cycle in G1/S phase and promotes apoptosis in tumor.
XNW5004 exhibits strong antitumor activity in EZH2-mutant lymphoma xenograft models, such as Karpas422 (Y641N), Pfeiffer (A677G) and SU-DHL-10 (Y641F).
XNW5004 exhibits dose-dependent efficacy in solid tumor models such as G401 (SMARCB1 deficient) and COV434 (SMARCA2/SMARCA4 deficient) cancer cell lines and xenografts.

物理化学性质&存储条件

分子量	550.74
分子式	C32H46N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2-methyl-5-[[trans-3-(1-piperidinyl)cyclobutyl]oxy]benzamide

参考文献

1. Yonghan Hu, et al. Cancer Res (2023) 83 (7_Supplement): 3089.

Igermetostat (XNW-5004, XNW5004)

生物&药学活性

物理化学性质&存储条件

参考文献

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Igermetostat (XNW-5004, XNW5004)

生物&药学活性

物理化学性质&存储条件

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