UNC10013 | SETDB1 modulator | Probechem Biochemicals

Chemical Structure : UNC10013

CAS No.:

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UNC10013 (UNC-10013)

货号: PC-23137Not For Human Use, Lab Use Only.

UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1.
UNC10013 has a kinact/KI of 1.0 x 106 M-1s-1 and demonstrates proteome-wide selectivity.
UNC10013 shows no significant direct inhibition of the methyltransferase activity of SETDB1 in vitro （IC50=64.9 uM.
UNC10013 exhibits negative allosteric modulator properties and making it a promising tool to study the biological role of SETDB1 in disease progression.

物理化学性质&存储条件

分子量	526.77
分子式	C29H50N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(dimethylamino)-N-(4-((6-(dimethylamino)hexyl)amino)-2-((5-(dimethylamino)pentyl)amino)quinazolin-6-yl)but-2-enamide

参考文献

1. Uguen M, et al. bioRxiv [Preprint]. 2024 Sep 28:2024.09.27.615363.
2. Uguen M, et al. Nat Commun. 2025 Feb 24;16(1):1905.

UNC10013 (UNC-10013)

生物&药学活性

物理化学性质&存储条件

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UNC10013 (UNC-10013)

生物&药学活性

物理化学性质&存储条件

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