YD1342

Chemical Structure : YD1342

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货号: PC-23238Not For Human Use, Lab Use Only.

YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM).

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生物&药学活性

YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM).
YD1342 exhibited potent inhibition on cellular substrate methylation, breast cancer cell colony formation, and tumor growth in the animal model.

物理化学性质&存储条件

分子量	727.68
分子式	C33H39BrN6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((((2S,3R,4R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-N-(3-bromobenzyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide

参考文献

1. Deng Y, et al. J Med Chem. 2024 Oct 3. doi: 10.1021/acs.jmedchem.4c01041.

YD1342

生物&药学活性

物理化学性质&存储条件

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YD1342

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