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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-DC-Y13-27
DC-Y13-27

Chemical Structure : DC-Y13-27

CAS No.:

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DC-Y13-27 (YTHDF2 inhibitor)

货号: PC-22471Not For Human Use, Lab Use Only.

DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay.
DC-Y13-27 display no activity against YTHDF1 (IC50=165.2 uM).
DC-Y13-27 enhances responses to radiotherapy and immunotherapy in a manner similar to the deletion of YTHDF2.

物理化学性质&存储条件

分子量 270.31
分子式 C14H10N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-cyano-3-(5-(3-hydroxyphenyl)thiophen-2-yl)acrylamide

参考文献

1. Wang L, et al. Cancer Cell. 2023 Jul 10;41(7):1294-1308.e8.

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