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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-Zolucatetide
Zolucatetide

Chemical Structure : Zolucatetide

CAS No.: 3044032-95-0

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Zolucatetide (FOG-001, I-66)

货号: PC-27045Not For Human Use, Lab Use Only.

Zolucatetide (FOG-001, I-66) is a potent β-catenin inhibitor with IC50 of <50 nM, inhibits β-catenin and T-cell factor (TCF) transcription factor PPI, inhibits cell proliferation and induces cell cycle arrest in target cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Zolucatetide (FOG-001, I-66) is a potent β-catenin inhibitor with IC50 of <50 nM, inhibits β-catenin and T-cell factor (TCF) transcription factor PPI, inhibits cell proliferation and induces cell cycle arrest in target cells.
    Zolucatetide inhibits β-catenin and T-cell factor (TCF) transcription factor interaction.
    Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells.
    Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts.

    物理化学性质&存储条件

    分子量 2076.42
    分子式 C102H134N18O25S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    L-Alaninamide, 12,42-(2Z)-2-hexene-1,6-diyl-1-acetyl-L-prolyl-L-α-aspartyl-4-methyl-L-leucyl-(2S,6E)-2-amino-10-(carboxyoxy)-6-decenoyl-L-α-aspartyl-3-carboxy-L-phenylalanyl-2-methylalanyl-L-alanyl-L-phenylalanyl-L-lysyl-(3S)-3-amino-3-pyrrolidinecarbonyl-3-(3-thienyl)-L-alanyl-3-benzo[b]thien-3-yl-L-alanyl-L-α-glutamyl-, (4→11),(14→10)-dilactam

    参考文献

    1. Patent WO2022261257A1.

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