Zolucatetide | β-catenin inhibitor | Probechem Biochemicals

Chemical Structure : Zolucatetide

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Zolucatetide (FOG-001, I-66)

货号: PC-27045Not For Human Use, Lab Use Only.

Zolucatetide (FOG-001, I-66) is a potent β-catenin inhibitor with IC50 of <50 nM.

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生物&药学活性

Zolucatetide (FOG-001, I-66) is a potent β-catenin inhibitor with IC50 of <50 nM.
Zolucatetide inhibits β-catenin and T-cell factor (TCF) transcription factor interaction.
Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells.
Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts.

物理化学性质&存储条件

分子量	2076.42
分子式	C102H134N18O25S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CCCCNC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@]3(CCN(C3)C(=O)OCCC/C=C/CCC[C@]4(CCC/C=C\C[C@]5(CCCN5C(=O)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CC(C)(C)C)CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(C(=O)N1)(C)C)CC6=CC(=CC=C6)C(=O)O)CC(=O)O)NC2=O)CC7=CSC=C7)CC8=CSC9=CC=CC=C98)C(=O)N[C@@H](C)C(=O)N)CC1=CC=CC=C1

参考文献

1. Patent WO2022261257A1.

Zolucatetide (FOG-001, I-66)

生物&药学活性

物理化学性质&存储条件

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Zolucatetide (FOG-001, I-66)

生物&药学活性

物理化学性质&存储条件

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