ZD-4009 (ZD4009)

Chemical Structure : ZD-4009

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货号: PC-28109Not For Human Use, Lab Use Only.

ZD-4009 is a potent and selective inhibitor of B-cell lymphoma 9 (BCL9), shows high-affinity binding to β-catenin with KD of 44.72 nM, shows antifibrotic efficacy.

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生物&药学活性

ZD-4009 is a potent and selective inhibitor of B-cell lymphoma 9 (BCL9), shows high-affinity binding to β-catenin with KD of 44.72 nM, shows antifibrotic efficacy.
ZD-4009 inhibited fibroblast activation, suppressed extracellular matrix deposition, and reduced the expression of fibrosis-associated markers, including collagen type I alpha 1 chain (COL1A1) and alpha-smooth muscle actin (α-SMA).
ZD-4009 suppresses HIF-1α-associated glycolytic reprogramming and inhibits transforming growth factor-β (TGF-β)/SMAD family member (SMAD) signaling.
ZD-4009 suppresses fibroblast proliferation and extracellular matrix deposition in idiopathic pulmonary fibrosis.
ZD-4009 shows favorable antifibrotic effects compared with nintedanib.

物理化学性质&存储条件

分子量	468.56
分子式	C27H28N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((5-(2-aminoethoxy)-4-(pyrrolidin-1-yl)pyrimidin-2-yl)amino)phenyl)-1-naphthamide

参考文献

1. Li A, et al. Mol Pharmacol. 2026 Jul 24;108(9):100144.

ZD-4009 (ZD4009)

生物&药学活性

物理化学性质&存储条件

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ZD-4009 (ZD4009)

生物&药学活性

物理化学性质&存储条件

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