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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-GB1874
GB1874

Chemical Structure : GB1874

CAS No.: 1011440-46-2

GB1874 (GB 1874, GB-1874)

货号: PC-73231Not For Human Use, Lab Use Only.

GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.
GB1874 affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro.
GB1874 inhibited the growth of CRC tumor xenografts in vivo.

物理化学性质&存储条件

分子量 421.559
分子式 C24H27N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((5-((4-ethylphenoxy)methyl)-4-(1-phenylethyl)-4H-1,2,4-triazol-3-yl)thio)cyclopentan-1-one

参考文献

1. Yannick D Benoit, et al. Cell Chem Biol. 2021 Oct 21;28(10):1394-1406.e10.

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