Miclxin (DS37262926)

Chemical Structure : Miclxin

CAS No.: 2494198-61-5

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货号: PC-38409Not For Human Use, Lab Use Only.

Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
Miclxin (DS37262926) exhibits selective induction of apoptosis in β-catenin-mutated HCT116 cells, which harbor deletion mutant of Ser45. Mutation at Ser45 of β-catenin is detected not only in colorectal tumor but in hepatocellular, prostate and uterine tumors. Miclxin-mediated MIC60 dysfunction induced mitochondrial stress response, leading to apoptosis-inducing factor (AIF)-dependent apoptosis.

物理化学性质&存储条件

分子量	441.535
分子式	C26H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-N-(3-methoxybenzyl)-2-(3-(pyridin-3-yl)pyrrolidin-1-yl)quinazolin-4-amine

参考文献

1. Hiroaki Ikeda, et al. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204.