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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-ICG-001
ICG-001

Chemical Structure : ICG-001

CAS No.: 780757-88-2

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ICG-001 (ICG001)

货号: PC-20622Not For Human Use, Lab Use Only.

ICG-001 (ICG001) is a specific small molecule inhibitor of TCF/beta-catenin, antagonizes β-catenin/TCF-mediated transcription with IC50 of 3 uM.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ICG-001 (ICG001) is a specific small molecule inhibitor of TCF/beta-catenin, antagonizes β-catenin/TCF-mediated transcription with IC50 of 3 uM.
ICG-001 binds specifically to CBP but not the related transcriptional coactivator p300, thereby disrupting the interaction of CBP with β-catenin.
ICG-001 also does not inhibit other CBP-dependent reporters, including AP-1 and CRE (IC50>100 uM).
ICG-001 induces apoptosis in colon carcinoma cells but not in normal colonic epithelial cells.
ICG-001 inhibits the expression of the TCF/β-catenin-mediated genes survivin and cyclin D1, ICG-001 down-regulates survivin and increases caspase activity in colon carcinoma cell lines.
ICG-001 (150 mg/kg, i.v.) is efficacious in both the Min mouse and nude mouse SW620 xenograft models of cancer.

物理化学性质&存储条件

分子量 548.63
分子式 C33H32N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

参考文献

1. Emami KH, et al. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12682-7.

2. Ma H, et al. Oncogene. 2005 May 19;24(22):3619-31.

3. Teo JL, et al. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12171-6.

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