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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Beta-catenin-RX-5902
RX-5902

Chemical Structure : RX-5902

CAS No.: 888478-45-3

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RX-5902 (Supinoxin, RX5902)

货号: PC-73060Not For Human Use, Lab Use Only.

RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.
RX-5902 directly binds to Y593 phospho-p68 RNA helicase, exhibits strong growth inhibition in various human cancer cell lines with IC50 values ranging between 10 and 20 nM.
RX-5902 inhibited the β-catenin dependent ATPase activity of p68 RNA helicase, downregulates the expression of certain genes in β-catenin pathway, such as c-Myc, cyclin D1 and p-c-Jun.
RX-5902 inhibits β-catenin signaling and demonstrates anti-tumor activity in triple-negative breast cancer (TNBC) in vivo.

物理化学性质&存储条件

分子量 441.463
分子式 C22H24FN5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,5-Dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl] piperazine

参考文献

1. Capasso A, et al. Mol Cancer Ther. 2019 Sep 5. pii: molcanther.1334.2018. doi: 10.1158/1535-7163.MCT-18-1334.

2. Kost GC, et al. J Cell Biochem. 2015 Aug;116(8):1595-601.

3. Ali W, et al. Prog Biophys Mol Biol. 2018 Dec;140:79-89.

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