HI-B1

Chemical Structure : HI-B1

CAS No.: 1458664-10-2

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货号: PC-20582Not For Human Use, Lab Use Only.

HI-B1 is a small molecule inhibitor of β-catenin/TCF4 interaction, directly targets β-catenin and disrupts β-catenin/TCF4 complex formation.

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5 mg	￥2780	In stock
25 mg	￥5980	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

HI-B1 is a small molecule inhibitor of β-catenin/TCF4 interaction, directly targets β-catenin and disrupts β-catenin/TCF4 complex formation.
HI-B1 suppresses growth of several types of colon cancer cells (DLD1, CACO2 and HCT116), but did not affect the H838 lung cancer cell line, preferentially kills cancer cells in which β-catenin is critical for survival.
HI-B1 directly binds with β-catenin and disrupts the β-catenin/TCF4 interaction
HI-B1 (50 mg/kg, oral) inhibits β-catenin-driven tumorigenesis in PDX colon cancer models.

物理化学性质&存储条件

分子量	255.30
分子式	C15H14FN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CN(C)C1=CC=C(C2=NC3=CC(F)=CC=C3N2)C=C1

参考文献

1. Seung Ho Shin, et al. EBioMedicine. 2017 Nov;25:22-31.

HI-B1

生物&药学活性

物理化学性质&存储条件

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HI-B1

生物&药学活性

物理化学性质&存储条件

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