| Cat. No. |
Product Name |
Information |
| PC-38769 |
ERP1.28a
CDC-7 inhibitor
|
ERP1.28a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 140 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS. |
| PC-38768 |
ERP1.14a
CDC-7 inhibitor
|
ERP1.14a is a selective, small molecule inhibitor of cell division cell cycle kinase 7 (CDC-7) with IC50 of 125 nM, decreases the enhanced TDP-43 phosphorylation in cells derived from TDP-43-related pathogenesis such as FTLD and ALS. |
| PC-38758 |
Zotiraciclib
CDK/JAK2/FLT3 inhibitor
|
Zotiraciclib (TG02, SB1317) is a potent multi-kinase inhibitor of cyclin dependent kinases (CDKs), JAK2, and FLT3 with IC50of 13, 73, and 56 nM for CDK2, JAK2 and FLT3, respectively. |
| PC-38750 |
ZNL-05-044
CDK11 inhibitor
|
ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity. |
| PC-38645 |
Cimpuciclib
CDK inhibitor
|
Cimpuciclib is a cyclin-dependent kinase(CDK) inhibitor with antineoplastic activity. |
| PC-38355 |
Dalpiciclib
CDK4/6 inhibitor
|
Dalpiciclib (SHR6390) is an orally bioavailable, small molecule CDK4/6 inhibitor, strongly inhibits tumor proliferation of ESCC in vitro and in vivo. |
| PC-38340 |
Avotaciclib
CDK1 inhibitor
|
Avotaciclib (BEY1107) is a potent, selective CDK1 (Cyclin-Dependent Kinase 1) inhibitor, inhibits self-replication of cancer stem cells and is a candidate for pancreatic cancer treatment. |
| PC-73446 |
Tanuxiciclib
CDK inhibitor
|
Tanuxiciclib is a potent cyclin dependent kinase (CDK) inhibitor. |
| PC-73414 |
Eciruciclib
CDK inhibitor
|
Eciruciclib is a potent cyclin dependent kinase (CDK) inhibitor with antineoplastic activities. |
| PC-73257 |
ASP9822
CDK7 inhibitor
|
ASP9822 is a novel potent selective CDK7 inhibitor with IC50 of 4.3 nM, with anti-cancer activity. |
| PC-73186 |
NCT02
CCNK-CDK12 degrader
|
NCT02 is a small moelcule that induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. |
| PC-73102 |
SR4835
CDK12/13 inhibitor
|
SR-4835 (SR4835) is a potent, highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 98 and 4.9 nM, respectively. |
