| Cat. No. |
Product Name |
Information |
| PC-26877 |
CDK17 inhibitor DU12
CDK17 inhibitor
|
DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM. |
| PC-26376 |
CTX-439
CDK12/13 inhibitor
|
CTX-439 is a potent, selective, orally bioavailable, ATP-competitive CDK12/13 inhibitor with IC50 of 3.1/ 9.2 nM towards CDK12/Cyclin K and CDK13/Cyclin K, respectively, in cell-free assays. |
| PC-25402 |
TP-1287
CDK9 inhibitor
|
TP-1287 is a prodrug of Alvocidib (Flavopiridol, HMR-1275), is an orally active CDK9 inhibitor. |
| PC-25358 |
CIRc-004
Cyclin A/B RxL inhibitor
|
CIRc-004 is a potent, cell-permeable dual cyclin A/B RxL inhibitor with IC50 of 0.13 and <0.02 uM for cyclin A1-CDK2 and cyclin B-CDK1, does not inhibit cyclin E1-CDK2, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity. |
| PC-24989 |
AU3-14
CDK4/6 inhibitor
|
Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM. |
| PC-24960 |
Mocaciclib
CDK7 inhibitor
|
Mocaciclib (Q901) is a highly selective and potent CDK7 inhibitor, forms a covalent bond with C312 of the CDK7 C-terminal domain. |
| PC-24915 |
AS3334366
CDK8/19 inhibitor, Foxp3 inducer
|
AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS3334366 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM. |
| PC-24914 |
AS2863619
CDK8/19 inhibitor, Foxp3 inducer
|
AS2863619 is a potent, selective and orally active inhibitor of CDK8 and CDK19 with IC50 of 0.61 nM and 4.28 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 32.5 nM. |
| PC-24657 |
Bireociclib
CDK4/6 inhibitor
|
Bireociclib (XZP-3287) is a novel potent, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor with IC50 of 2.7/16 nM respectively. |
| PC-24530 |
Tagtociclib hydrate
CDK2 inhibitor
|
Tagtociclib hydrate (PF-07104091 hydrate, Tegtociclib hydrate) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
| PC-24325 |
SNX631-6
CDK8/19 inhibitor
|
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively. |
| PC-23995 |
BLU-222
CDK2 inhibitor
|
Cirtociclib (BLU-222) is a potent, highly selective, ATP-competitive CDK2 inhibitor with IC50 of 2.6 nM (CDK2/cyclinE1) with strong selectivity (>200-fold) over CDK family members (1/4/6/7/9). |
