| Cat. No. |
Product Name |
Information |
| PC-21963 |
dCeMM3
Cyclin K degrader
|
dCeMM3 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
| PC-21962 |
dCeMM2
Cyclin K degrader
|
dCeMM2 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
| PC-21922 |
LDC3140
CDK7 inhibitor
|
LDC3140 is a potent, selective CDK7 inhibitor with IC50 of <5 nM, >500-fold selective over CDK1/2/4/6/9. |
| PC-21886 |
CVT-313
CDK2 inhibitor
|
CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E. |
| PC-21703 |
CP681301
CDK5 inhibitor
|
CP681301 is a potent, highly specific CDK5 inhibitor, completely inhibits both CDK5-P35 and CDK5-P25 at 1 uM. |
| PC-21681 |
XPW1
CDK9 inhibitor
|
XPW1 is a potent and selective CDK9 inhibitor with excellent anti-ccRCC activity and low toxicity. |
| PC-21527 |
TMX-2039
pan CDK inhibitor
|
TMX-2039 is a pan-CDK inhibitor with low nanomolar enzymatic IC50s (0.5-50 nM) for both cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). |
| PC-21053 |
HQ461
cyclin K degrader
|
HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM. |
| PC-20887 |
CDK2 inhibitor 5
CDK2 inhibitor
|
CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1. |
| PC-20691 |
NCGC00131308
IQGAP1-Cdc42 inhibitor
|
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays. |
| PC-49786 |
MER-128
CDK20 inhibitor
|
MER-128 is a potent, selective CDK20 inhibitor with IC50 of 2 nM. |
| PC-49698 |
EF-4-177
CDK2 inhibitor
|
EF-4-177 is a potent, selective, allosteric and orally active CDK2 inhibitor with ITC KD of 7.4 nM.
EF-4-177 binds CDK2 in a manner that is negatively cooperative with cyclin binding. |
