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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-AZD-5438
AZD-5438

Chemical Structure : AZD-5438

CAS No.: 602306-29-6

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AZD-5438 (AZD 5438, AZD5438)

货号: PC-42060Not For Human Use, Lab Use Only.

AZD-5438 (AZD5438) potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD-5438 (AZD5438) potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively.
AZD-5438 also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro, displays 75-fold less active against cyclin D-Cdk4.
AZD-5438 shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7 uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle.
AZD-5438 inhibits the human tumor xenograft growth in vivo.
AZD-5438 also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a β-lactam-synergism-dependent manner.

物理化学性质&存储条件

分子量 371.4566
分子式 C18H21N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-

参考文献

1. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66.

2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.

3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.

4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.

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