Dinaciclib (SCH 727965) | CDK inhibitor | Probechem Biochemicals

Chemical Structure : Dinaciclib

CAS No.: 779353-01-4

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Dinaciclib (SCH727965, SCH-727965)

货号: PC-42616Not For Human Use, Lab Use Only.

Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
Dinaciclib (SCH 727965) completely suppresses Rb phosphorylation and inhibits bromodeoxyuridine incorporation in >100 tumor cell lines.
Dinaciclib (SCH 727965) exhibits superior activity with an improved therapeutic index compared with flavopiridol.

物理化学性质&存储条件

分子量	396.486
分子式	C21H28N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 56 mg/mL
Chemical Name/SMILES	2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-

参考文献

1. Parry D, et al. Mol Cancer Ther. 2010 Aug;9(8):2344-53.

2. Paruch K, et al. ACS Med Chem Lett. 2010 May 17;1(5):204-8.

3. Feldmann G, et al. Cancer Biol Ther. 2011 Oct 1;12(7):598-609.

4. Johnson AJ, et al. Leukemia. 2012 Dec;26(12):2554-7.

Dinaciclib (SCH727965, SCH-727965)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dinaciclib (SCH727965, SCH-727965)

生物&药学活性

物理化学性质&存储条件

参考文献

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