JNJ-7706621 |CAS:443797-96-4 Probechem Biochemicals

Chemical Structure : JNJ-7706621

CAS No.: 443797-96-4

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JNJ-7706621 (JNJ7706621;JNJ 7706621)

货号: PC-42527Not For Human Use, Lab Use Only.

JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively.
JNJ-7706621 also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM), and no activity for Plk1 or Wee1.
JNJ-7706621 arrests the cell cycle at the G2-M phase.
JNJ-7706621 shows significant antitumor activity in tumor xenograft model.

物理化学性质&存储条件

分子量	394.356
分子式	C15H12F2N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-

参考文献

1. Emanuel S, et al. Cancer Res. 2005 Oct 1;65(19):9038-46.

2. Huang S, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41.

3. Seamon JA, et al. Mol Cancer Ther. 2006 Oct;5(10):2459-67.

JNJ-7706621 (JNJ7706621;JNJ 7706621)

生物&药学活性

物理化学性质&存储条件

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JNJ-7706621 (JNJ7706621;JNJ 7706621)

生物&药学活性

物理化学性质&存储条件

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