| Cat. No. |
Product Name |
Information |
| PC-42965 |
Kenpaullone
CDK nhibitor
|
Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM). |
| PC-42956 |
LY2857785
CDK9 inhibitor
|
LY2857785 is a potenrt, reversible and ATP-competitive CDK9 inhibitor with IC50 of 11 nM, also inhibits CDK8 (IC50=16 nM) and weakly inhibits CDK7 (IC50=246 nM). |
| PC-42944 |
THZ2
CDK7 inhibitor
|
THZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1. |
| PC-63139 |
TAK-931
Cdc7 inhibitor
|
TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM. |
| PC-63127 |
Enitociclib
CDK9 inhibitor
|
Enitociclib ((±)-BAY-1251152) is a potent, highly specific P-TEFb/CDK9 inhibitor with IC50 of 3 nM. displays> 50-fold selectivity against other CDKs. |
| PC-63041 |
TAME hydrochloride
APC/C inhibitor
|
TAME hydrochloride is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1). |
| PC-63040 |
proTAME
APC/C inhibitor
|
proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20). |
| PC-63039 |
Apcin
Cdc20 inhibitor
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
| PC-62864 |
CAN508
CDK9 inhibitor
|
CAN508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM). |
| PC-62848 |
CDK9-IN-4d
CDK9 inhibitor
|
CDK9-IN-4d is a highly potent, selective CDK9 inhibitor with IC50 of 12 nM, shows good selectivity in CDKs kinase profiling assay against CDK kinases and cell proliferation inhibition. |
| PC-62821 |
CGP-74514A hydrochloride
CDK1 inhibitor
|
CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM. |
| PC-62682 |
Ibulocydine
CDK7/9 inhibitor
|
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively. |
