(R)-CR8 | CDK inhibitor | Probechem Biochemicals

Chemical Structure : (R)-CR8

CAS No.: 294646-77-8

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(R)-CR8 (CR8 R-isomer, CR8)

货号: PC-38299Not For Human Use, Lab Use Only.

(R)-CR8 is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

(R)-CR8 (CR8) is a potent CDK1/2/5/7/9 inhibitor, inhibits CDK1/cyclin B (IC50, 90 nM), CDK2/cyclin A (72 nM), CDK2/cyclin E (41 nM), CDK5/p25 ( 110 nM), CDK7/cyclin H (1.1 uM), CDK9/cyclin T (0.18 uM) and CK1δ/ε (0.4 uM).
(R)-CR8 induces apoptosis and has neuroprotective effect.
CR8 binds CDK12-cyclin K and recruits the DDB1–CUL4–RBX1 E3 ligase core to ubiquitinate cyclin K
(R)-CR8 also acts as a molecular glue degrader that depletes cyclin K.

物理化学性质&存储条件

分子量	431.544
分子式	C24H29N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1

参考文献

1. Słabicki M, et al. Nature. 2020 Sep;585(7824):293-297.

2. Huang BY, et al. CNS Neurosci Ther. 2019 May;25(5):612-620.

3. Husson H, et al. Hum Mol Genet. 2016 Jun 1;25(11):2245-2255.

4. Delehouzé C, et al. Oncogene. 2014 Dec 11;33(50):5675-87.

(R)-CR8 (CR8 R-isomer, CR8)

生物&药学活性

物理化学性质&存储条件

参考文献

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(R)-CR8 (CR8 R-isomer, CR8)

生物&药学活性

物理化学性质&存储条件

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