Ebvaciclib (PF-06873600) | CDK2/4/6 inhibitor | Probechem Biochemicals

Chemical Structure : PF-06873600

CAS No.: 2185857-97-8

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PF-06873600 (Ebvaciclib, PF3600, PF 06873600)

货号: PC-35969Not For Human Use, Lab Use Only.

PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively.
PF-06873600 (Ebvaciclib) demonstrates potential antineoplastic activity, incerease apoptosis and inhibits umor cell proliferation.

物理化学性质&存储条件

分子量	471.524
分子式	C20H27F2N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-

参考文献

1. Freeman-Cook K, et al. Cancer Cell. 2021 Oct 11;39(10):1404-1421.e11.
2. Freeman-Cook KD, et al. J Med Chem. 2021 Jul 8;64(13):9056-9077.

PF-06873600 (Ebvaciclib, PF3600, PF 06873600)

生物&药学活性

物理化学性质&存储条件

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询单

PF-06873600 (Ebvaciclib, PF3600, PF 06873600)

生物&药学活性

物理化学性质&存储条件

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