SY-5102 | CDK7 inhibitor | Probechem Biochemicals

Chemical Structure : SY-5102

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SY-5102 (SY5102)

货号: PC-72466Not For Human Use, Lab Use Only.

SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).

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生物&药学活性

SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).
SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).
SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.
SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.

物理化学性质&存储条件

分子量	457.45
分子式	C22H22F3N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(6-(3,5-Dimethylisoxazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidin-2-amine hydrochloride

参考文献

1. Jason J Marineau, et al. J Med Chem. 2022 Jan 27;65(2):1458-1480.

SY-5102 (SY5102)

生物&药学活性

物理化学性质&存储条件

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SY-5102 (SY5102)

生物&药学活性

物理化学性质&存储条件

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