FMF-04-159-2 | 2364489-81-4 Probechem Biochemicals

Chemical Structure : FMF-04-159-2

CAS No.: 2364489-81-4

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FMF-04-159-2 (CDK14 inhibitor)

货号: PC-36163Not For Human Use, Lab Use Only.

FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).

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10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).
FMF-04-159-2 potently inhibited the TAIRE kinases CDK14, CDK16, CDK17, and CDK18.
CDK14 was potently engaged by FMF-04-159-2 (IC50=39.6 nM), and this engagement was sustained after a 2-h, compound washout (IC50=56.3 nM), indicates irreversible binding.
FMF-04-159-2 is a valuable tool for study of CDK14 kinase function.

物理化学性质&存储条件

分子量	683.002
分子式	C28H30Cl3N7O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(1-((3-(4-(dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

参考文献

1. Ferguson FM, et al. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.

FMF-04-159-2 (CDK14 inhibitor)

生物&药学活性

物理化学性质&存储条件

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FMF-04-159-2 (CDK14 inhibitor)

生物&药学活性

物理化学性质&存储条件

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