A-1592668 | CDK9 inhibitor | Probechem Biochemicals

Chemical Structure : A-1592668

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A-1592668 (A 1592668)

货号: PC-38149Not For Human Use, Lab Use Only.

A-1592668 (A 1592668) is a novel potent, CDK9-selective inhibitor with IC50 of 1.2 nM, >1000 fold selectivity over CDK1/2/7/8.

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生物&药学活性

A-1592668 (A 1592668) is a novel potent, CDK9-selective inhibitor with IC50 of 1.2 nM, >1000 fold selectivity over CDK1/2/7/8.
A-1592668 also displays selectivity of ~12- and 240-fold over CDK4 and CDK6 respectively.
A-1467729 inhibited phosphorylation of RNA pol-II (p-RNA pol-II; Ser2) with a potency of 26.7 nM at the cellular level, inhibited MCL-1 dependent hematologic tumor cell lines H929 (IC50=39 nM) and MV4-11 (IC50=42.4 nM) following 24 h of incubation.

物理化学性质&存储条件

分子量	467.517
分子式	C26H27F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-(4-(5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,6-dihydropyridin-1(2H)-yl)cyclohexane-1-carboxylic acid

参考文献

1. Darren C Phillips, et al. Leukemia. 2020 Jun;34(6):1646-1657.

A-1592668 (A 1592668)

生物&药学活性

物理化学性质&存储条件

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A-1592668 (A 1592668)

生物&药学活性

物理化学性质&存储条件

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