| Cat. No. |
Product Name |
Information |
| PC-20872 |
Ribociclib
CDK4/6 inhibitor
|
Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively. |
| PC-20589 |
Abemaciclib
CDK4/6 inhibitor
|
Abemaciclib (LY2835219) is a potent, selective and ATP-competitive CDK4/6 inhibitor with Ki values of 0.6 and 2.4 nM for CDK4/cyclin D1 and CDK6/cyclin D1, respectively. |
| PC-20566 |
Apcin-A
APC inhibitor, Cdc20 inhibitor
|
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. |
| PC-20494 |
Cdk5i peptide
Cdk5/p25 inhibitor
|
Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone. |
| PC-20345 |
Cdc25A inhibitor 7h
Cdc25A inhibitor
|
Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20344 |
Cdc25A inhibitor 7g
Cdc25A inhibitor
|
Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
| PC-20316 |
LDC4297
CDK7 inhibitor
|
LDC4297 (LDC044297) is a potent, highly specific CDK7 inhibitor with IC50 of 7.4 nM in ATP competition assays (3.5 mM ATP), weakly inhibits CDK2 (IC50>2 uM). |
| PC-20315 |
LGR6768
CDK7 inhibitor
|
LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs. |
| PC-20284 |
QR-6401
CDK2 inhibitor
|
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor. |
| PC-20283 |
PF-07104091
CDK2 inhibitor
|
Tagtociclib (PF-07104091) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
| PC-20219 |
CDK8 inhibitor 32
CDK8 inhibitor
|
CDK8 inhibitor 32 is a potent selective CDK8 inhibitor with IC50 of 1.5 nM, reduces phosphorylation of the known CDK8 substrate STAT1 in a manner identical to a CDK8 knockout clone. |
| PC-49792 |
SGC-CDKL5/GSK3-1
CDKL5/GSK3 inhibitor
|
CDKL5/GSK3 inhibitor 2 is a highly potent and cell-active chemical probe inhibitor of cyclindependent kinase-like 5 (CDKL5)/GSK3 (glycogen synthase kinase 3) with IC50 of 4.6/9.5/24 nM for CDKL5/GSK3⍺/GSK3β, respectively. |
