欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-YK-2168
YK-2168

Chemical Structure : YK-2168

CAS No.: 2571068-74-9

加入收藏

YK-2168 (YK2168)

货号: PC-23019Not For Human Use, Lab Use Only.

YK-2168 is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

YK-2168 is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2.
YK-2168 exhibits cell viability potency (IC50=53.4 nM) against MV4-11 cells, inhibits the CDK9 signaling and induced apoptosis.
YK-2168 demonstrated dose dependent anti-tumor effects, resulted in many mouse partial responses (PR) in a mouse gastric cancer SNU16 CDX model.

物理化学性质&存储条件

分子量 315.81
分子式 C16H18ClN5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-chloro-4-(1-methyl-1H-pyrazol-4-yl)-2-(piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine

参考文献

1. Liu Y, et al. Bioorg Med Chem Lett. 2024 Aug 31:129941.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: