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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Tacaciclib
Tacaciclib

Chemical Structure : Tacaciclib

CAS No.: 2768774-66-7

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Tacaciclib (AUR-102, XL-102, XL102, AUR102)

货号: PC-23060Not For Human Use, Lab Use Only.

Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor.
Tacaciclib (XL102, AUR102) selectively targets, covalently binds to and inhibits the activity of CDK7, thereby inhibiting CDK7-mediated signaling.
Tacaciclib (XL102, AUR102) prevents phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II, thereby preventing transcription of important cancer-promoting genes.

物理化学性质&存储条件

分子量 528.65
分子式 C30H36N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(αS)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-α-(1-methylethyl)-3-[6-[[(2E)-4-(4-morpholinyl)-1-oxo-2-buten-1-yl]amino]-3-pyridinyl]benzeneacetamide

参考文献

1. Amita Patnaik, et al. Cancer Res (2023) 83 (5_Supplement): P4-01-35.

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