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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-CVT-313
CVT-313

Chemical Structure : CVT-313

CAS No.: 199986-75-9

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CVT-313 (CVT313)

货号: PC-21886Not For Human Use, Lab Use Only.

CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E.
CVT-313 displays 8.5-fold and 430-fold selectivity over CDK1 and CDK4, 2500-fold over mitogen-activated protein kinase and protein kinase A, and PKC.
CVT-313 inhibits cell proliferation at the G1/S or G2/M boundary (Caco-2 cell, IC50=4.5 uM).
CVT-313 inhibits Rb phosphorylation, inhibits neointima formation in rat carotid artery model of restenosis.

物理化学性质&存储条件

分子量 400.48
分子式 C20H28N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2{-bis-(hydroxyethyl)amino}-6-(4-methoxybenzyl-amino)-9-isopropyl-purine

参考文献

1. Bhattacharjee RN, et al. Mol Cell Biol. 2001 Aug;21(16):5417-25.

2. Brooks EE, et al. J Biol Chem. 1997 Nov 14;272(46):29207-11.

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