KY-065 | CDK8 inhibitor | Probechem Biochemicals

Chemical Structure : KY-065

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KY-065 (KY065)

货号: PC-23612Not For Human Use, Lab Use Only.

KY-065 is a potent, selective and ATP-competitive CDK8/19 inhibitor with IC50 of 4.4/3.6 nM respectively, without affecting the activities of other CDK family members.

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生物&药学活性

KY-065 is a potent, selective and ATP-competitive CDK8/19 inhibitor with IC50 of 4.4/3.6 nM respectively, without affecting the activities of other CDK family members.
KY-065 also does not markedly inhibit the kinase activities of 30 serine/threonine kinases through a single point inhibition assay.
KY-065 ameliorates the suppressive differentiation in chondrocytes of Fgfr3Ach mice.
KY-065 decreases STAT1Ser727 phosphorylation in chondrocytes of Fgfr3Ach mice, with no significant effect on the phosphorylation level of STAT1Tyr701.
KY-065 elongates the long bone and improves growth plate cytoarchitecture in Fgfr3Ach mice.

物理化学性质&存储条件

分子量	399.44
分子式	C22H25NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-acetyl-3-4-[2-(tetrahydropyran-4-yloxy)ethoxy]phenoxybenzamide

参考文献

1. Sadamori K, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 12:167626.

KY-065 (KY065)

生物&药学活性

物理化学性质&存储条件

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KY-065 (KY065)

生物&药学活性

物理化学性质&存储条件

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