CDK9 inhibitor VC-1 | CDK9 inhibitor | Probechem Biochemicals

Chemical Structure : CDK9 inhibitor VC-1

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CDK9 inhibitor VC-1 (VC-1, VCC972839:01)

货号: PC-22380Not For Human Use, Lab Use Only.

CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.

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生物&药学活性

CDK9 inhibitor VC-1 is a potent, selective CDK9 inhibitor, inhibits SCLC cell viability with IC50 of 7 nM, does not inhibit other CDKs, such as CDK1, 2 and 5.
VC-1 reduces MCL-1 and cFLIP anti-apoptotic proteins and killed cells, almost exclusively, by intrinsic apoptosis.
VC-1does not synergise with chemotherapy, but dispalys high efficacy in chemotherapy-resistant cells.
VC-1 effectively reduced tumour growth and improved survival in both autochthonous and syngeneic SCLC models.

物理化学性质&存储条件

分子量	408.47
分子式	C24H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((1H-benzo[d]imidazol-1-yl)methyl)phenyl)-4-(2-methoxyphenyl)-1,3,5-triazin-2-amine

参考文献

1. Valdez Capuccino L, et al. Cell Death Dis. 2024 May 20;15(5):345.

CDK9 inhibitor VC-1 (VC-1, VCC972839:01)

生物&药学活性

物理化学性质&存储条件

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CDK9 inhibitor VC-1 (VC-1, VCC972839:01)

生物&药学活性

物理化学性质&存储条件

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