BPI-16350 | CDK4/6 inhibitor | Probechem Biochemicals

Chemical Structure : BPI-16350

加入收藏

BPI-16350 (Tibremciclib, BPI 16350)

货号: PC-23058Not For Human Use, Lab Use Only.

BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM).
BPI-16350 is far less active against other CDKs, such as CDK1/cyclinB, CDK2/cyclinE, CDK5/p25, and CDK7/cyclinH complexes.
BPI-16350 inhibits cell proliferation and viability by arresting cells at G1 phase.
BPI-16350 inhibited tumor growth by 71.7%, 89.5%, and 98.5% at dosages of 37.5, 75, and 150 mg/kg, respectively, in COLO 205 xenografts.

物理化学性质&存储条件

分子量	518.62
分子式	C28H32F2N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[(1R)-6-fluoro-1,2,3,4-tetrahydro-1-methylpyrido[1,2-a]benzimidazol-8-yl]-2-pyrimidinamine

参考文献

1. Jian Zhang, et al. 2023 ASCO Annual Meeting I

BPI-16350 (Tibremciclib, BPI 16350)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BPI-16350 (Tibremciclib, BPI 16350)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.