CDK9 inhibitor C35

Chemical Structure : CDK9 inhibitor C35

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货号: PC-26368Not For Human Use, Lab Use Only.

CDK9 inhibitor C35 is a potent, selective and orally bioavailable CDK9 inhibitor with IC50 of 17.44 nM, shows 18-fold selectivity over CDK2.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CDK9 inhibitor C35 is a potent, selective and orally bioavailable CDK9 inhibitor with IC50 of 17.44 nM, shows 18-fold selectivity over CDK2.
C35 exhibits noteworthy growth inhibition activities across three TNBC cell lines, with IC50 values ranging from 5 to 10 nM.
C35 effectively inhibited the phosphorylation on RPB1 CTD Ser2, a downstream target of CDK9 in TNBC cells.
C35 (10 mg/kg, p.o. daily) significantly suppressed the tumor progression in TNBC mouse models, significantly reduced the transcription level of the MCL1 gene in MDA-MB-231 xenografts and 4T1 allografts.

物理化学性质&存储条件

分子量	437.55
分子式	C23H31N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(((8-isopropyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)propionamide

参考文献

1. Wang WJ, et al. J Med Chem. 2024 Jun 27;67(12):10035-10056.