SNS-032 |CAS:345627-80-7 Probechem Biochemicals

Chemical Structure : SNS-032

CAS No.: 345627-80-7

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SNS-032 (BMS-387032)

货号: PC-42052Not For Human Use, Lab Use Only.

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
25 mg	￥880	In stock
50 mg	￥1380	In stock
100 mg	￥2280	In stock
250 mg		Get quote

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生物&药学活性

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively.
SNS-032 (BMS-387032) displays 10- and 20-fold selective over CDK1/cycB and CDK4/cycD (IC50=480 and 925 nM) respectively, and a panel of unrelated kinases, respectively.
SNS-032 (BMS-387032) blocks the cell cycle via inhibition of CDKs 2 and 7, and transcription via inhibition of CDKs 7 and 9, has an A2780 cellular cytotoxicity assay IC50 of 95 nM.
SNS-032 (BMS-387032) exhibits a efficacy profile in A2780 human ovarian carcinoma xenograft model.

物理化学性质&存储条件

分子量	380.528
分子式	C17H24N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-

参考文献

1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.

2. Mukhopadhyay P, et al. Cancer Res. 2006 Feb 1;66(3):1758-66.

3. Chen R, et al. Blood. 2009 May 7;113(19):4637-45.

4. Heath EI, et al. Invest New Drugs. 2008 Feb;26(1):59-65.

SNS-032 (BMS-387032)

生物&药学活性

物理化学性质&存储条件

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SNS-032 (BMS-387032)

生物&药学活性

物理化学性质&存储条件

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