RO8323 | CDK8/19 inhibitor | Probechem Biochemicals

Chemical Structure : RO8323

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RO8323 (RO-8323)

货号: PC-26497Not For Human Use, Lab Use Only.

RO8323 is a potent and selective dual CDK8/19 inhibitor with IC50 of 2/3 nM respectively, has 100-fold kinome selectivity.

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生物&药学活性

RO8323 is a potent and selective dual CDK8/19 inhibitor with IC50 of 2/3 nM respectively, has 100-fold kinome selectivity.
RO8323 promotes Treg differentiation and suppresses effector T cells in vitro and in vivo.
RO8323 transcriptionally represses pro-inflammatory programs in activated CD4+ T cells.
RO8323 potentiates IL-10 production in TLR-stimulated immune cells in vitro and in vivo.
RO8323 attenuates transplant rejection, prevents cGVHD and attenuates renal pathology in mice.
RO8323 increases Treg populations and enhances immune reconstitution in cGVHD mice. prolongs cardiac allograft survival in mice.

物理化学性质&存储条件

分子量	315.38
分子式	C19H17N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N12C(C=C3C=C2)=C(CC4=CC(CCCN5C=NN=C53)=CC=C4)N=C1

参考文献

1. Shen F, et al. Acta Pharmacol Sin. 2026 Mar 31.

RO8323 (RO-8323)

生物&药学活性

物理化学性质&存储条件

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RO8323 (RO-8323)

生物&药学活性

物理化学性质&存储条件

参考文献

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