P162-0948

Chemical Structure : P162-0948

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货号: PC-23694Not For Human Use, Lab Use Only.

P162-0948 is a potent, selective cyclin-dependent kinase 8 (CDK8) inhibitor with IC50 of 50.4 nM, disrupts TGF-β1-induced cell migration.

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生物&药学活性

P162-0948 is a potent, selective cyclin-dependent kinase 8 (CDK8) inhibitor with IC50 of 50.4 nM, disrupts TGF-β1-induced cell migration.
P162-0948 displays high selectivity over 60 different kinases, including the structurally closest CDK9.
P162-0948 (5 uM) exhibits cytotoxicity and migration inhibition in A549 cells.
P162-0948 suppresseS the expression of EMT proteins in human alveolar epithelial cells.
P162-0948 inhibits TGF-β1-induced p-Smad3 T179 and RNA polymerase II pS2/S5 in A549 cells.

物理化学性质&存储条件

分子量	362.36
分子式	C20H15FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorobenzyl)-2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide

参考文献

1. Tony Eight Lin, et al. J Chem Inf Model. 2024 Dec 31. doi: 10.1021/acs.jcim.4c02011.

P162-0948

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物理化学性质&存储条件

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P162-0948

生物&药学活性

物理化学性质&存储条件

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