RGB-286199 | CDK inhibitor | Probechem Biochemicals

Chemical Structure : RGB-286199

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RGB-286199 (RGB286199, GPC-286199)

货号: PC-21090Not For Human Use, Lab Use Only.

RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.

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生物&药学活性

RGB-286199 (GPC-286199) is a potent broad spectrum CDKs (cyclin dependent kinases) inhibitor with IC50 of 5-100 nM against CDKs 1-6, shows antiproliferative activity in vitro and in vivo.
RGB-286199 (50 nM) causes loss of phosphorylation of Rb protein, accompanied by loss of cyclin A protein, in the human colon carcinoma cell line HCT-116 treated in vitro.
RGB-286199 has significant antitumor efficacy in vivo against several human xenograft models at tolerated doses.

物理化学性质&存储条件

分子量	573.65
分子式	C30H35N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(4-(2-(4-isopropylpiperazin-1-yl)-2-oxoethoxy)phenyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl)-3-morpholinourea

参考文献

1. Shaoshan Wang, et al. Cancer Res (2005) 65 (9_Supplement): 1048.

RGB-286199 (RGB286199, GPC-286199)

生物&药学活性

物理化学性质&存储条件

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询单

RGB-286199 (RGB286199, GPC-286199)

生物&药学活性

物理化学性质&存储条件

参考文献

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