Ribociclib (LEE011)| CDK4/6 inhibitor | Probechem Biochemicals

Chemical Structure : Ribociclib

CAS No.: 1211441-98-3

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Ribociclib (LEE-011, LEE011)

货号: PC-20872Not For Human Use, Lab Use Only.

Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively.
Ribociclib suppresses neuroblastoma growth in vitro with IC50 of 306 nM against 12 of the 17 neuroblastoma cell lines.
Ribociclib causes cell-cycle arrest and cellular senescence and dose-dependently decreases in phosphorylated RB and FOXM1, respectively.
Ribociclib (200 mg/kg ) causes tumor growth delay in vivo in neuroblastoma cell-line derived xenografts.

物理化学性质&存储条件

分子量	434.55
分子式	C23H30N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

参考文献

1. Rader J, et al. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

2. Zhang YX, et al. Mol Cancer Ther. 2014 Sep;13(9):2184-93.

Ribociclib (LEE-011, LEE011)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ribociclib (LEE-011, LEE011)

生物&药学活性

物理化学性质&存储条件

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