HQ461 | cyclin K degrader | Probechem Biochemicals

Chemical Structure : HQ461

CAS No.: 1226443-41-9

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HQ461 (HQ-461)

货号: PC-21053Not For Human Use, Lab Use Only.

HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
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生物&药学活性

HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM.
HQ461 acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK).
HQ461 is a new molecular glue that recruits its target protein directly to DDB1 to bypass the requirement of a substrate-specific receptor, presenting a new strategy for targeted protein degradation.

物理化学性质&存储条件

分子量	345.44
分子式	C15H15N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((6-methylpyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide

参考文献

1. Lu Lv, et al. Elife. 2020 Aug 17;9:e59994. doi: 10.7554/eLife.59994.

HQ461 (HQ-461)

生物&药学活性

物理化学性质&存储条件

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HQ461 (HQ-461)

生物&药学活性

物理化学性质&存储条件

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