Cyclin K degrader DS17

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Cyclin K degrader DS17

Chemical Structure : Cyclin K degrader DS17

CAS No.:

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货号: PC-21140Not For Human Use, Lab Use Only.

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
25 mg		Get quote
100 mg		Get quote

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纯度 & COA & 质检文件 纯度: 99.64% (HPLC) Select Batch:

生物&药学活性

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 13 nM.
Cyclin K degrader DS17 is more effective at depleting cyclin K than CR8 at 1 µM concentration.
Cyclin K degrader DS17 acquires glue activity via simultaneous CDK12 binding and engagement of DDB1 interfacial residues, in particular Arg928.

物理化学性质&存储条件

分子量	463.37
分子式	C20H24Cl2N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((6-(((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

参考文献

1. Zuzanna Kozicka, et al. Nat Chem Biol. 2023 Sep 7. doi: 10.1038/s41589-023-01409-z.

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