欢迎访问ProbeChem中文网站,英文网站请访问www.probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Flavopiridol hydrochloride
Flavopiridol hydrochloride

Chemical Structure : Flavopiridol hydrochloride

CAS No.: 131740-09-5

Flavopiridol hydrochloride (HL 275, NSC 649890, MDL 107826A, Alvocidib Hydrochloride)

货号: PC-42050Not For Human Use, Lab Use Only.

Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.

规格 价格 库存 数量
10 mg ¥580 In stock
25 mg ¥980 In stock
50 mg ¥1680 In stock
100 mg ¥2680 In stock
250 mg Get quote

大包装,大折扣!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Flavopiridol (Alvocidib) inhibits cell cycle progression in either G1 or G2 in human breast carcinoma cells, induces programmed cell death, promote differentiation, inhibits angiogenic processes and modulates transcriptional events.

物理化学性质&存储条件

分子量 438.3011
分子式 C21H21Cl2NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)

参考文献

1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40.

2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.

3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.

4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.

备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: