Flavopiridol (HMR-1275, Alvocidib) | CDK inhibitor | Probechem Biochemicals

Chemical Structure : Flavopiridol

CAS No.: 146426-40-6

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Flavopiridol (L-868275, HMR-1275, Alvocidib, NSC 649890)

货号: PC-42049Not For Human Use, Lab Use Only.

Flavopiridol (HMR-1275, Alvocidib) is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1680	In stock
100 mg		Get quote

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生物&药学活性

Flavopiridol (HMR-1275, Alvocidib) is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
Flavopiridol (HMR-1275, Alvocidib) inhibits cell cycle progression in either G1 or G2 in human breast carcinoma cells, induces programmed cell death, promote differentiation, inhibits angiogenic processes and modulates transcriptional events.

物理化学性质&存储条件

分子量	401.8402
分子式	C21H20ClNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-

参考文献

1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40.

2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.

3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.

4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.

Flavopiridol (L-868275, HMR-1275, Alvocidib, NSC 649890)

生物&药学活性

物理化学性质&存储条件

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Flavopiridol (L-868275, HMR-1275, Alvocidib, NSC 649890)

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物理化学性质&存储条件

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