Ro-3306 | CDK1 inhibitor | Probechem Biochemicals

Chemical Structure : Ro-3306

CAS No.: 872573-93-8

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Ro-3306 (Ro3306)

货号: PC-43098Not For Human Use, Lab Use Only.

Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.
Ro-3306 also inhibits CDK1/cyclin A complexes with Ki of 110 nM, shows >15-fold selectivity against a diverse panel of 8 human kinases.
Ro-3306 reversibly arrests human cells at the G(2)/M border of the cell cycle and allows for effective cell synchronization in early mitosis.
Ro-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.

物理化学性质&存储条件

分子量	351.4453
分子式	C18H13N3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 47 mg/mL
Chemical Name/SMILES	4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-

参考文献

1. Vassilev LT, et al. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10660-5.

2. Kojima K, et al. Cancer Sci. 2009 Jun;100(6):1128-36.

3. Krasinska L, et al. Cell Cycle. 2008 Jun 15;7(12):1702-8.

4. Vassilev LT. Cell Cycle. 2006 Nov;5(22):2555-6.

Ro-3306 (Ro3306)

生物&药学活性

物理化学性质&存储条件

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Ro-3306 (Ro3306)

生物&药学活性

物理化学性质&存储条件

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