FIT-039 |CAS:1113044-49-7 Probechem Biochemicals

Chemical Structure : FIT-039

CAS No.: 1113044-49-7

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FIT-039 (FIT039)

货号: PC-63455Not For Human Use, Lab Use Only.

FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).
FIT-039 shows no marked inhibitory effect on CDK4/cyclinD3, does not inhibit other CDKs, including CDK2/cyclinB1, CDK2/cyclinE1, CDK5/p25, CDK6/cyclinD3, or CDK7/cyclinH/MAT.
FIT-039 suppresses viral replication without affecting the host cell cycle, inhibits viral transcription; also inhibits HBV propagation and HIV-1 replication.
FIT-039 suppresses HPV viral oncogenes E6 and E7, and shows therapeutic rffect on HPV-induced neoplasia in vivo.

物理化学性质&存储条件

分子量	315.41
分子式	C17H18FN3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide

参考文献

1. Yamamoto M, et al. J Clin Invest. 2014 Aug;124(8):3479-88.

2. Okamoto M, et al. Antiviral Res. 2015 Nov;123:1-4.

3. Tanaka T, et al. Antiviral Res. 2016 Sep;133:156-64.

4. Ajiro M, et al. Clin Cancer Res. 2018 Apr 30. pii: clincanres.3119.2017.

FIT-039 (FIT039)

生物&药学活性

物理化学性质&存储条件

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FIT-039 (FIT039)

生物&药学活性

物理化学性质&存储条件

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