CDK inhibitor E9 |CAS:2020052-55-3 Probechem Biochemicals

Chemical Structure : CDK inhibitor E9

CAS No.: 2020052-55-3

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CDK inhibitor E9 (E9)

货号: PC-63235Not For Human Use, Lab Use Only.

CDK inhibitor E9 is a novel CDK inhibitor that can overcomes ABC-mediated resistance of THZ1, functions as a potent, non-covalent inhibitor of CDK9 and a covalent inhibitor of CDK12.

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10 mg	￥5480	In stock
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生物&药学活性

CDK inhibitor E9 is a novel CDK inhibitor that can overcomes ABC-mediated resistance of THZ1, functions as a potent, non-covalent inhibitor of CDK9 and a covalent inhibitor of CDK12.
CDK inhibitor E9 does not serve as a substrate for either ABCB1 or ABCG2, while avoiding ABC transporter-mediated efflux.
CDK inhibitor E9 decreases the phosphorylated and total RNAPII in THZ1R NB and lung cancer cells (IC50=8-40 nM), accompanied by decreased MYC and MCL1 expression, exerts its cytotoxic effects through covalent modification of cysteine 1039 of CDK12.

物理化学性质&存储条件

分子量	434.544
分子式	C24H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)phenyl)acrylamide

参考文献

1. Gao Y, et al. Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5.

CDK inhibitor E9 (E9)

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物理化学性质&存储条件

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CDK inhibitor E9 (E9)

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