HSD992 |CAS: 2222045-50-1 Probechem Biochemicals

Chemical Structure : HSD992

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HSD992 (HSD 992;HSD-992)

货号: PC-63305Not For Human Use, Lab Use Only.

HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively.

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生物&药学活性

HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively.
HSD992 only poorly inhibits the activities of CDKs 1, 4, 5, 6, 14, 16, 17, 18 and 19, and does not inhibit PLK isoforms.
HSD992 inhibits HLY-1 and NCI-H520 with IC50 values of 232 nM and 307 nM, respectively, The IC50 values against other cell lines (LC-2/Ad, K562, HeLa, NCI-H1703 and DMS114) ranged from 427 nM to 723 nM.

物理化学性质&存储条件

分子量	370.474
分子式	C22H18N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(8,9,10,11-tetrahydro-3H-pyrrolo[3,2-a]phenanthridin-7-yl)benzo[d]thiazol-2-amine

参考文献

1. Opoku-Temeng C, et al. Chem Commun (Camb). 2018 Apr 9. doi: 10.1039/c8cc01154k.

HSD992 (HSD 992;HSD-992)

生物&药学活性

物理化学性质&存储条件

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HSD992 (HSD 992;HSD-992)

生物&药学活性

物理化学性质&存储条件

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