| Cat. No. |
Product Name |
Information |
| PC-60103 |
BETd-260 trifluoroacetate
BET PROTAC
|
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60102 |
BETd-260
BET PROTAC
|
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL. |
| PC-60100 |
CDK9 PROTAC 1
CDK9 PROTAC
|
CDK9 PROTAC 1 is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9. |
| PC-60099 |
MZ1
BRD4 PROTAC
|
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers and induces degradation of the BET bromodomain BRD4. |
| PC-60096 |
Sirt2 PROTAC 1
Sirt2 PROTAC
|
Sirt2 PROTAC 1 is a SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM). |
| PC-42297 |
ARV-771
BET PROTAC
|
ARV-771 (ARV771) is a potent BET degrader (PROTAC), potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. |
| PC-45097 |
ARV-825
BRD4 PROTAC
|
ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. |
| PC-27578 |
PinA1 hydrochloride
CK1⍺ degrader
|
PinA1 hydrochloride is a potent, preferential molecular glue degrader targeting CK1⍺ with DC50 of 46.9 nM in Jurkat cells (16 h), degrades CK1α via CRBN-dependent ubiquitination. |
| PC-27544 |
SMARCA2 4 MGD Compound 1
SMARCA2/4 degrader
|
SMARCA2/4 MGD Compound 1 is a DCAF16-selective molecular glue degrader of SMARCA2/4 with DC50 of 38.1 nM/ 7.1 nM, degrades SMARCA2/4 exclusively via DCAF16, driven by covalent capture of Cys173. |
| PC-27523 |
MD-4251
MDM2 degrader
|
MD-4251 is a potent, selective and orally efficacious MDM2 PROTAC degrader with DC50 of 0.2 nM in RS4;11 cells (Dmax=96% at 2 h), leading to robust p53 activation. |
| PC-27441 |
YTHDC1 PROTAC XY-2
YTHDC1 degrader
|
YTHDC1 PROTAC XY-2 is a selective, efficient PROTAC degrader of N6-Methyladenosine (m6A) reader YTHDC1 with DC50 of 11.42 nM in MOLM13 and 13.59 nM in Kasumi-1 cells respectively. |
| PC-27389 |
NE26394
CDK4 degrader
|
NE26394 is a first-in-class, selective molecular glue degrader (MGD) of cyclin-dependent kinase 4 (CDK4) with DC50 of 163 nM and Dmax=93%, induces CDK4 recognition by CRBN depending on the co recruitment of endogenous INK4 family proteins. |
