MS4322 | PRMT5 degrader | Probechem Biochemicals

Chemical Structure : MS4322

CAS No.: 2375432-47-4

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MS4322 (MS-4322)

货号: PC-72471Not For Human Use, Lab Use Only.

MS4322 (MS-4322) is a potent, highly selective PRMT5 degrader (PROTAC) by linking the PRMT5 inhibitor EPZ015666 to a von Hippel-Lindau (VHL) E3 ligase ligand, with PRMT5 protein DC50 of 1.1 uM in MCF-7 cells.

规格	价格	库存
1 mg	￥4280	In stock
2 mg	￥7280	In stock
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10 mg		Get quote

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生物&药学活性

MS4322 (MS-4322) is a potent, highly selective PRMT5 degrader (PROTAC) by linking the PRMT5 inhibitor EPZ015666 to a von Hippel-Lindau (VHL) E3 ligase ligand, with PRMT5 protein DC50 of 1.1 uM in MCF-7 cells.
MS4322 effectively reduced PRMT5 protein levels in multiple cell lines, reduced the PRMT5 protein level in MCF7 cells in a concentration-, time-, VHL- and proteasome-dependent manner.
MS4322 inhibited cell growth at least as effectively as EPZ015666 in multiple cancer cell lines and exhibited good plasma exposure in a mouse pharmacokinetic (PK) study.

物理化学性质&存储条件

分子量	1101.32
分子式	C55H76N10O12S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide

参考文献

1. Yudao Shen, et al. J Med Chem. 2020 Sep 10;63(17):9977-9989.

MS4322 (MS-4322)

生物&药学活性

物理化学性质&存储条件

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MS4322 (MS-4322)

生物&药学活性

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