| Cat. No. |
Product Name |
Information |
| PC-24732 |
Aster-A PROTAC NGF3
Aster-A degrader
|
Aster-A PROTAC NGF3 is a VHL-based PROTAC degrader of GRAM domain containing 1A (GRAMD1A, Aster-A) with DC50 of 4.8 uM, Dmax=60%, in HeLa cells. |
| PC-24675 |
Linker-free PROTAC Pro-DA
BCR-ABL degrader
|
Linker-free PROTAC Pro-DA is a linker-free PROTAC degarder of BCR-ABL protein with DC50 of 8 nM in K562 cells, achieving a 93% reduction at 20 nM, shows cell growth IC50 of 0.9 nM. |
| PC-24674 |
Linker-free PROTAC Pro-BA
EML4-ALK degrader
|
Linker-free PROTAC Pro-BA is a linker-free PROTAC degarder of EML4-ALK protein with DC50 of 74 nM and achieves an 82% reduction at 500 nM in H3122 cells, shows cell growth IC50 of 34 nM. |
| PC-24663 |
GDC-2992
AR PROTAC
|
GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells. |
| PC-24558 |
MNK1 PROTAC P11-2
MNK1 PROTAC
|
MNK1 PROTAC P11-2 is a first-in-class, selective MNK1-targeting PROTAC degrader with DC50 of 11.92 nM (MV4-11 cells), Dmax>96%, shows remarkable selectivity for MNK1 over MNK2. |
| PC-24557 |
ERD-1233
ERα degrader
|
ERD-1233 is a potent and orally efficacious PROTAC degrader of estrogen receptor α (ERα) with DC50 of 0.9 nM in MCF-7 cell line, Dmax=100%. |
| PC-24506 |
LZK PROTAC 17
LZK degrader
|
LZK PROTAC 17 is a potent, selective PROTAC degrader of leucine zipper-bearing kinase (LZK, MAP3K13) with binding Kd of 71 nM, potently degrades LZK at 250 nM and suppresses HNSCC viability at 500 nM. |
| PC-24493 |
YD54
SMARCA2 PROTAC
|
YD54 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 1.2 nM (H322 cell ine), Dmax=99.3%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
| PC-24492 |
YDR1
SMARCA2 PROTAC
|
YDR1 is potent, selective, and orally bioavailable SMARCA2 degrading PROTAC with DC50 of 6.3 nM (H322 cell ine), Dmax=99.4%, selectively inhibit gowth of SMARCA4 mutant lung cancer cell lines. |
| PC-24420 |
KMG-1068
GSPT1/2 degrader
|
KMG-1068 is a selective GSPT1/2-targeting molecular glue degrader, binds CRBN through a non-IMiD mechanism, induces proteasomal degradation of GSPT1/2 with DC50 of 126.7 nM for GSPT1 and 42.2 nM for GSPT2 in Jurkat cells. |
| PC-24384 |
MS6178
CFTR DUBTAC
|
MS6178 is a MS5105-based CFTR DUBTAC, significantly increases the CFTR mutant protein level, stabilizes CFTR in a concentration-dependent manner. |
| PC-24383 |
MS7131
USP1-based UTX DUBTAC
|
MS7131 is a first-in-class USP1-recruiting UTX (KDM6A, Ubiquitously transcribed tetratricopeptide repeat X chromosome) deubiquitinase-targeting chimera (DUBTAC), selectively stabilizes the tumor suppressor UTX, but not the oncoprotein JMJD3. |
