GDC-2992 | AR PROTAC | Probechem Biochemicals

Chemical Structure : GDC-2992

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GDC-2992 (RO7656594)

货号: PC-24663Not For Human Use, Lab Use Only.

GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells.

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生物&药学活性

GDC-2992 (Compound 28A) is a potent, selective and orally active androgen receptor (AR) PROTAC degrader with DC50 of 2.7 nM, inhibits proliferation with IC50 of 9.7 nM in VCaP cells.

物理化学性质&存储条件

分子量	819.40
分子式	C45H51ClN8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[[4-[2-[(3S)-2,6-dioxo-3-piperidinyl]-1,2-dihydro-1-oxo-6-phthalazinyl]-1-piperazinyl]methyl]-1-piperidinyl]-

参考文献

1. Patent WO2024107686 A1.

GDC-2992 (RO7656594)

生物&药学活性

物理化学性质&存储条件

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GDC-2992 (RO7656594)

生物&药学活性

物理化学性质&存储条件

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