| Cat. No. |
Product Name |
Information |
| PC-38302 |
Helios degrader ALV1
Helios degrader
|
Helios degrader ALV1 (ALV-03-112-01) is a small molecule degrader of the zinc-finger transcription factor Helios with IC50 of 0.55 uM in CRBN-binding TR-FRET assay. |
| PC-38232 |
DDC-01-163
EGFR PROTAC
|
DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected. |
| PC-38185 |
SHP2-D26
SHP2 PROTAC
|
SHP2-D26 is a potent and effective SHP2 degrader (PROTAC) with DC50 of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4. |
| PC-38182 |
SHP2 PROTAC R1-5C
SHP2 PROTAC
|
SHP2 PROTAC R1-5C is a potent and highly selective SHP2 PROTAC created by conjugating RMC-4550 with pomalidomide using a PEG linker, with a low nanomolar DC50. |
| PC-38058 |
BSJ-4-116
CDK12 degrader
|
BSJ-4-116 is a potent, CDK12 specific degrader (PROTAC) with IC50 of 6 nM, exhibits anti-proliferative activity in cancer cells. |
| PC-38054 |
DT2216
BCL-XL PROTAC
|
DT2216 (DT-2216) is a specific BCL-XL PROTAC by linking ABT263 to a VHL ligand (VHL-L), induces BCL-XL degradation in MOLT-4 T-ALL cells with DC50 of 63 nM. |
| PC-38047 |
Bavdegalutamide
AR PROTAC
|
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR with DC50 of <1 nM. |
| PC-38019 |
dCBP-1
p300/CBP PROTAC
|
dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC. |
| PC-36168 |
Rpn13 degrader WL40
Rpn13 PROTAC
|
Rpn13 degrader WL40 (WL40) is a novel covalent ubiquitin receptor Rpn13 degrader by linking the Rpn13 covalent inhibitor RA190 with the cereblon (CRBN) binding ligand thalidomide. |
| PC-36151 |
NRX-252114
|
NRX-252114 (NRX 252114, NRX252114) is a potent, small molecule β-TrCP-based degrader of β-catenin, potentiates pSer33/S37A β-catenin binding and ubiquitylation (EC50=6.5 nM). |
| PC-36067 |
BI-3663
FAK PROTAC
|
BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines. |
| PC-35936 |
BSJ-03-123
CDK6 PROTAC
|
BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions. |
